11 September 1989 Laserthermia And New PDT In Neurosurgery
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The usefulness of laserthermia using Nd:YAG laser was studied experimentally and clinically to treat deep seated brain tumor. Histological changes, temperature profile, modification of blood-brain barrier (BBB) were studied. Five patients with brain tumors were treated with laserthermia. Laserthermia using Nd:YAG laser is easy and safe to use and it is beneficial to treat deep seated brain tumor. Photodynamic therapy (PDT) was also evaluated using the photosensitizing agent pheophorbide-a (Ph-a) and an acoustic Q switched Nd:YAG laser. In xitro survival of T98G human glioma cells pretreated with Ph-a (1x10-3 mole/1 in albumin) and irradiated with a pulsed Nd:YAG laser for 5 minutes at 37.0°C was 0.4%. The present study suggested that PDT using an acoustic Q switched Nd:YAG laser and Ph-a was useful in treating experimental human glioma.
© (1989) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
T. Sakai, T. Sakai, I. Fujishima, I. Fujishima, K. Sugiyama, K. Sugiyama, } "Laserthermia And New PDT In Neurosurgery", Proc. SPIE 1066, Laser Surgery: Advanced Characterization, Therapeutics, and Systems, (11 September 1989); doi: 10.1117/12.952056; https://doi.org/10.1117/12.952056


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