8 August 1989 Intracoronary Doppler: Clinical Application And Future Directions
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Because coronary arteriography may underestimate the severity of coronary artery disease, other methods to assess the physiologic significance of a coronary lesion have been sought. Experimental data have confirmed that the ratio of peak flow to resting flow, coronary vasodilator reserve (CVDR), is a quantitative measure of the functional significance of a coronary a stenosis. A 20 MHz pulsed Doppler catheter with a 1 mm outer diameter and an innerlumen for guidewire placement was developed in 1985 and has been used for clinical measurement of CVDR. The technique appears safe, and reliable signals can be obtained in the vast majority of patients studied. Limitations of the technique include possible changes in vessel diameter with delivery of a vasodilator stimulus, possible elevation of baseline flow above normal resting values which would diminish the CVDR, and inability to measure absolute coronary flow. These limitations could be overcome by the development of an intravascular Echo-Doppler device in the future.
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Patrick L. Whitlow, Patrick L. Whitlow, Russell E. Raymond, Russell E. Raymond, E. Murat Tuzcu, E. Murat Tuzcu, } "Intracoronary Doppler: Clinical Application And Future Directions", Proc. SPIE 1068, Catheter-Based Sensing and Imaging Technology, (8 August 1989); doi: 10.1117/12.952167; https://doi.org/10.1117/12.952167

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