17 May 2018 Multiphoton tomography and multimodal OCT for in vivo visualization of oral malignancy in the hamster cheek pouch
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Abstract
The main purpose of this work is to evaluate the possibility to distinguish in vivo benign papilloma, severe dysplasia and squamous cell carcinoma by establishing quantitative image characteristics of multiphoton tomography (MPT) and multimodal optical coherence tomography images (MM OCT). Specific features of papillomatous outgrowths at different stages were revealed using 7,12-dimethylbenz[a]anthracen (DMBA)-induced hamster oral carcinoma. Analysis of MPT images included assessment of nuclear-cytoplasmic (NC) ratio, nuclear density and heterogeneity parameter F. Crosspolarization OCT images were quantified via the integral depolarization factor (IDF). Analysis of OCT microvascular maps enabled differential analysis based on the number of smallest-diameter blood vessels present in a particular pathology. Both MPT and MM OCT metrics showed some difference between benign papilloma, dysplastic papilloma, and squamous cell carcinoma tissue states. The results suggested that combined use of MPT and MM OCT have great potential for in vivo differentiation between benign and malignant papillomas.
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Vadim Elagin, Vadim Elagin, Maria Karabut, Maria Karabut, Elena Kiseleva, Elena Kiseleva, Marina Sirotkina, Marina Sirotkina, Varvara Dudenkova, Varvara Dudenkova, Nadezhda Pavlova, Nadezhda Pavlova, Sergey Kuznetsov, Sergey Kuznetsov, Lev Matveev, Lev Matveev, Alexander Moiseev, Alexander Moiseev, Anastasia Shumilova, Anastasia Shumilova, Felix Feldchtein, Felix Feldchtein, Elena Zagaynova, Elena Zagaynova, Alex Vitkin, Alex Vitkin, Natalia Gladkova, Natalia Gladkova, } "Multiphoton tomography and multimodal OCT for in vivo visualization of oral malignancy in the hamster cheek pouch", Proc. SPIE 10685, Biophotonics: Photonic Solutions for Better Health Care VI, 106852T (17 May 2018); doi: 10.1117/12.2306210; https://doi.org/10.1117/12.2306210
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