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17 May 2018 Multiphoton tomography and multimodal OCT for in vivo visualization of oral malignancy in the hamster cheek pouch
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The main purpose of this work is to evaluate the possibility to distinguish in vivo benign papilloma, severe dysplasia and squamous cell carcinoma by establishing quantitative image characteristics of multiphoton tomography (MPT) and multimodal optical coherence tomography images (MM OCT). Specific features of papillomatous outgrowths at different stages were revealed using 7,12-dimethylbenz[a]anthracen (DMBA)-induced hamster oral carcinoma. Analysis of MPT images included assessment of nuclear-cytoplasmic (NC) ratio, nuclear density and heterogeneity parameter F. Crosspolarization OCT images were quantified via the integral depolarization factor (IDF). Analysis of OCT microvascular maps enabled differential analysis based on the number of smallest-diameter blood vessels present in a particular pathology. Both MPT and MM OCT metrics showed some difference between benign papilloma, dysplastic papilloma, and squamous cell carcinoma tissue states. The results suggested that combined use of MPT and MM OCT have great potential for in vivo differentiation between benign and malignant papillomas.
© (2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Vadim Elagin, Maria Karabut, Elena Kiseleva, Marina Sirotkina, Varvara Dudenkova, Nadezhda Pavlova, Sergey Kuznetsov, Lev Matveev, Alexander Moiseev, Anastasia Shumilova, Felix Feldchtein, Elena Zagaynova, Alex Vitkin, and Natalia Gladkova "Multiphoton tomography and multimodal OCT for in vivo visualization of oral malignancy in the hamster cheek pouch", Proc. SPIE 10685, Biophotonics: Photonic Solutions for Better Health Care VI, 106852T (17 May 2018);

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