Use of fluorescent optical fibre probe for recording parameters of brain metabolism in rat model

Olga Stelmashchuk; Evgeniya Seryogina; Gennadii Piavchenko M.D.; Alexander Alekseyev M.D.; Evgeny Zherebtsov; Andrey Dunaev; Ilya Rafailov; Evgeny Vorobyev; Alyona Kuznetsova; Elena Kuznetsova; Edik Rafailov

doi:10.1117/12.2290317

17 May 2018 Use of fluorescent optical fibre probe for recording parameters of brain metabolism in rat model

Olga Stelmashchuk, Evgeniya Seryogina, Gennadii Piavchenko M.D., Alexander Alekseyev M.D., Evgeny Zherebtsov, Andrey Dunaev, Ilya Rafailov, Evgeny Vorobyev, Alyona Kuznetsova, Elena Kuznetsova, Edik Rafailov

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Proceedings Volume 10685, Biophotonics: Photonic Solutions for Better Health Care VI; 106854R (2018) https://doi.org/10.1117/12.2290317
Event: SPIE Photonics Europe, 2018, Strasbourg, France

Abstract

This studiy was carried out on groups of clinically healthy male Wistar rats. Animals received distilled drinking water ad libitum for 1 month, water containing succinic acid, water containing zinc sulphate and succinate zinc. Using the method of fluorescence spectroscopy, the parameters of brain metabolism in vivo in a model of laboratory rats was investigated. Based on data obtained by fluorescence spectroscopy, we have registered a change in the degree of cellular respiration in different structures of the cerebral cortex with the toxic effect of zinc compounds and succinic acid on the oxygen exchange process.

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Olga Stelmashchuk, Evgeniya Seryogina, Gennadii Piavchenko M.D., Alexander Alekseyev M.D., Evgeny Zherebtsov, Andrey Dunaev, Ilya Rafailov, Evgeny Vorobyev, Alyona Kuznetsova, Elena Kuznetsova, and Edik Rafailov "Use of fluorescent optical fibre probe for recording parameters of brain metabolism in rat model", Proc. SPIE 10685, Biophotonics: Photonic Solutions for Better Health Care VI, 106854R (17 May 2018); https://doi.org/10.1117/12.2290317

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KEYWORDS

Zinc

Brain

Luminescence

Mode conditioning cables

Water

Fluorescence spectroscopy

Cerebral cortex

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