24 April 2018 Visible resonance Raman spectroscopy detect key molecular biomarker vibrations to characterize for human brain gliomas
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Proceedings Volume 10711, Biomedical Imaging and Sensing Conference; 107110O (2018) https://doi.org/10.1117/12.2318751
Event: SPIE Structured Light, 2018, Yokohama, Japan
Abstract
Visible resonant Raman (VRR) spectroscopy provides an effective way to enhance Raman signal from particular bonds associated with key molecules due to changes on molecular level. This paper reports on the VRR use for detection of human brain the control and gliomas of three grades. From the RR spectra additional two molecular vibrational biomarkers at 1129cm-1 and 1338cm-1, for the four types of brain tissues are significantly different in intensity. The new RR spectral peaks can be used as molecular biomarkers to evaluate glioma grades and identify the margin of gliomas from the controls. The metabolic process of glioma cells based on the RR spectral changes may reveal the Warburg hypothesis.
© (2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Yan Zhou, Yan Zhou, Cheng-hui Liu, Cheng-hui Liu, Binlin Wu, Binlin Wu, Xinguang Yu, Xinguang Yu, Gangge Cheng, Gangge Cheng, Chunyuan Zhang, Chunyuan Zhang, Hong Chen, Hong Chen, Shenglin Li, Shenglin Li, Rui Zong, Rui Zong, Qijun Liang, Qijun Liang, Ce Zhang, Ce Zhang, Mingqian Zhang, Mingqian Zhang, Cuicui Lu, Cuicui Lu, Ke Zhu, Ke Zhu, Robert R. Alfano, Robert R. Alfano, } "Visible resonance Raman spectroscopy detect key molecular biomarker vibrations to characterize for human brain gliomas", Proc. SPIE 10711, Biomedical Imaging and Sensing Conference, 107110O (24 April 2018); doi: 10.1117/12.2318751; https://doi.org/10.1117/12.2318751
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