Characterization of cancer metastasis in model mice by multiphoton microscopy and Raman spectroscopy

Yusuke Oshima; Shigehiro Koga; Hiromi Yamamoto; Yuji Watanabe

doi:10.1117/12.2317041

24 April 2018 Characterization of cancer metastasis in model mice by multiphoton microscopy and Raman spectroscopy

Yusuke Oshima, Shigehiro Koga, Hiromi Yamamoto, Yuji Watanabe

Proceedings Volume 10711, Biomedical Imaging and Sensing Conference; 107110X (2018) https://doi.org/10.1117/12.2317041
Event: SPIE Structured Light, 2018, Yokohama, Japan

Abstract

Raman spectroscopy provides a wealth of diagnostic information to the surgeon with in situ cancer detection and labelfree histopathology in clinical practice. However, to identify cancer diagnostic biomarkers in vivo is still challenging, because malignancy can be characterized not only by the cancer cells but also by the environmental factors. Here we investigate molecular dynamics in both cancer cells and their environment in xenograft models and spontaneous metastasis models using Raman spectroscopy and nonlinear optical imaging. We are constructing a custom-designed Raman spectral imaging system to reveal the metastasis process and to evaluate therapeutics toward the clinical application of the technique.

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Yusuke Oshima, Shigehiro Koga, Hiromi Yamamoto, and Yuji Watanabe "Characterization of cancer metastasis in model mice by multiphoton microscopy and Raman spectroscopy", Proc. SPIE 10711, Biomedical Imaging and Sensing Conference, 107110X (24 April 2018); https://doi.org/10.1117/12.2317041

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