Monitoring protein-related degeneration of Drosophila eyes with optical coherence tomography

Chia-Heng Wu; Cihun-Siyong Alex Gong; Min-Tsan Su; Meng-Tsan Tsai

doi:10.1117/12.2319077

24 April 2018 Monitoring protein-related degeneration of Drosophila eyes with optical coherence tomography

Chia-Heng Wu, Cihun-Siyong Alex Gong, Min-Tsan Su, Meng-Tsan Tsai

Proceedings Volume 10711, Biomedical Imaging and Sensing Conference; 1071113 (2018) https://doi.org/10.1117/12.2319077
Event: SPIE Structured Light, 2018, Yokohama, Japan

Abstract

Drosophila melanogaster has become an invertebrate genetic model for studies of genes-related diseases and developmental biology. Neurodegenerative diseases such Alzheimer and Parkinson’s diseases are health problem and get worse with age. However, the causes and progress of neurodegenerative diseases are still poorly understood. The compound eye of Drosophila demonstrates a heterologous system to investigate neurodegenerative diseases. In this study, we propose to use optical coherence tomography (OCT) for the study of protein-related degeneration of Drosophila eyes. With OCT, the bristles of Drosophila eye can be identified and different mutant Drosophila were scanned with OCT for investigation of progress of protein-related degeneration. From the results, it can be noted that OCT could be a powerful and noninvasive inspection tool for protein-related degenerative diseases.

Citation Download Citation

Chia-Heng Wu, Cihun-Siyong Alex Gong, Min-Tsan Su, and Meng-Tsan Tsai "Monitoring protein-related degeneration of Drosophila eyes with optical coherence tomography", Proc. SPIE 10711, Biomedical Imaging and Sensing Conference, 1071113 (24 April 2018); https://doi.org/10.1117/12.2319077

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