24 April 2018 Polarization-resolved second-harmonic-generation imaging of dermal collagen fiber in pre-wrinkled skin of ultraviolet-B-exposed mouse
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Proceedings Volume 10711, Biomedical Imaging and Sensing Conference; 107111H (2018) https://doi.org/10.1117/12.2319360
Event: SPIE Structured Light, 2018, Yokohama, Japan
Abstract
Wrinkling is a typical symptom of cutaneous photoaging in skin; however, mechanism of such wrinkling is still not clear. In this paper, we investigated orientation change of dermal collagen fiber in pre-wrinkled skin of ultraviolet-B-exposed (UVB-exposed) skin using polarization-resolved second-harmonic-generation (SHG) microscopy. A polarization anisotropic image of the SHG light indicated that change of collagen fiber orientation started in the pre-wrinkled skin of ultraviolet-B-exposed (UVB-exposed) mouse. Furthermore, the dominant direction of collagen fiber orientation was significantly parallel to the wrinkle direction in post-wrinkled skin of UVB-exposed mouse. This result implies that change of collagen fiber orientation is a trigger of wrinkling in photo-aged skin.
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Shu-ichiro Fukushima, Makoto Yonetsu, Eiji Hase, Takeshi Yasui, "Polarization-resolved second-harmonic-generation imaging of dermal collagen fiber in pre-wrinkled skin of ultraviolet-B-exposed mouse ", Proc. SPIE 10711, Biomedical Imaging and Sensing Conference, 107111H (24 April 2018); doi: 10.1117/12.2319360; https://doi.org/10.1117/12.2319360
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