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26 April 2018 Reduction of intoxication in the rats with transplanted tumors under the influence of Gratiola officinalis L. extract
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Abstract
This study focuses on the effect of the flavonoid-containing Gratiola officinalis L. extract with antitumor activity on the intensity of peroxidation and the content of vitamin E in the blood serum of animals with transplanted liver cancer PC-1. Intramuscular and oral administrations of the Gratiola officinalis extract in a dose of 110 mg/kg reduce MDA concentration (more than 20 times) and lipid hydroperoxide (more than 1.5 times) in rats with transplanted tumors. This effect leads to decrease in intensity of lipid peroxidation processes in animals. The Gratiola officinalis extract administration increases the vitamin E concentration (more than 1.3 times) in the serum of rats. This result enables to suggest that the extract of Gratiola officinalis contains the tocopherols. Thus, the study of mechanisms of the Gratiola officinalis extract influence on the activity of peroxidation processes and on the activation of the antioxidant system is promising.
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N. A. Navolokin, A. V. Polukonova, I. L. Plastun, D. A. Mudrak, A. N. Bokarev, G. A. Afanasyeva, A. B. Bucharskaya, G. N. Maslyakova, and N. V. Polukonova "Reduction of intoxication in the rats with transplanted tumors under the influence of Gratiola officinalis L. extract", Proc. SPIE 10716, Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX, 107160U (26 April 2018); https://doi.org/10.1117/12.2315342
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