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26 April 2018 Er:YLF-laser microperforation of the nail plate for drug delivery
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Laser microperforation of a human nail plate is an effective method to increase the speed of local drugs delivery in the treatment of nail diseases. In this paper we present the study results of the influence of spatial parameters of Er:YLFlaser- produced microhole array in human nail plate (the diameter of microholes and their packing density) on the rate (vsp) of 0.25 % water-alcohol solution of methylene blue penetration through a single microhole and on the time (Tmp) required for uniform distribution of this drug under the nail plate. In experiments, the diameter of microholes was 220 ± 10 μm, 300 ± 10 μm or 350 ± 10 μm. The packing density for microholes of each of these diameters was 100 μholes/cm2, 400 μholes/cm2 and 950 μholes/cm2. It is shown that vsp is mainly determined by the microhole diameter, and the packing density does not have a significant influence on it. It was experimentally established that the rate vsp is maximal for microholes with 350 μm diameter at packing density of 950 μholes/cm2 and reaches a value of 6.3 μm/s, and the time Tmp is minimal and equal to 180 ± 10 s at the same values of microhole diameter and packing density.
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Andrey V. Belikov, Alexei V. Skrypnik, Andrey N. Sergeev, Sergey N. Smirnov, and Anastasia D. Tavalinskaya "Er:YLF-laser microperforation of the nail plate for drug delivery", Proc. SPIE 10716, Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX, 107160X (26 April 2018);

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