26 April 2018 Sapphire shaped crystals for laser-assisted cryodestruction of biological tissues
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We have developed cryo-applicators based on the sapphire shaped crystals fabricated using the edge-defined film-fed growth (EFG) and noncapillary shaping (NCS) techniques. Due to the unique physical properties of sapphire: i.e. high thermal, mechanical, and chemical strength, impressive thermal conductivity and optical transparency, these cryo-applicators yield combination of the tissue cryo-destruction with its exposure to laser radiation for controlling the thermal regimes of cryosurgery, and with the optical diagnosis of tissue freezing. We have applied the proposed sapphire cryo-applicators for the destruction of tissues in vitro. The observed results highlight the prospectives of the sapphire cryo-applicators in cryosurgery.
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I. A. Shikunova, I. A. Shikunova, E. N. Dubyanskaya, E. N. Dubyanskaya, A. A. Kuznetsov, A. A. Kuznetsov, G. M. Katyba, G. M. Katyba, I. N. Dolganova, I. N. Dolganova, E. E. Mukhina, E. E. Mukhina, N. V. Chernomyrdin, N. V. Chernomyrdin, K. I. Zaytsev , K. I. Zaytsev , V. V. Tuchin, V. V. Tuchin, V. N. Kurlov, V. N. Kurlov, } "Sapphire shaped crystals for laser-assisted cryodestruction of biological tissues", Proc. SPIE 10716, Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX, 1071615 (26 April 2018); doi: 10.1117/12.2306134; https://doi.org/10.1117/12.2306134

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