Noninvasive control of rhodamine-loaded capsules distribution in vivo

O. Stelmashchuk; Y. Tarakanchikova; E. Seryogina; G. Piavchenko; E. Zherebtsov; A. Dunaev; A. Popov; I. Meglinski

doi:10.1117/12.2315773

26 April 2018 Noninvasive control of rhodamine-loaded capsules distribution in vivo

O. Stelmashchuk, Y. Tarakanchikova , E. Seryogina, G. Piavchenko, E. Zherebtsov, A. Dunaev, A. Popov, I. Meglinski

Proceedings Volume 10716, Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX; 1071619 (2018) https://doi.org/10.1117/12.2315773
Event: Saratov Fall Meeting 2017, 2017, Saratov, Russian Federation

Abstract

Using fluorescence spectroscopy system with fibre-optical probe, we investigated the dynamics of propagation and circulation in the microcirculatory system of experimental nanocapsules fluorescent-labelled (rhodamine TRITC) nanocapsules. The studies were carried out in clinically healthy Wistar rats. The model animals were divided into control group and group received injections of the nanocapsules. The fluorescent measurements conducted transcutaneously on the thigh surface. The administration of the preparation with the rhodamine concentration of 5 mg/kg of animal weight resulted in twofold increase of fluorescence intensity by reference to the baseline level. As a result of the study, it was concluded that fluorescence spectroscopy can be used for transdermal measurements of the rhodamine-loaded capsules in vivo.

Citation Download Citation

O. Stelmashchuk, Y. Tarakanchikova , E. Seryogina, G. Piavchenko, E. Zherebtsov, A. Dunaev, A. Popov, and I. Meglinski "Noninvasive control of rhodamine-loaded capsules distribution in vivo", Proc. SPIE 10716, Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX, 1071619 (26 April 2018); https://doi.org/10.1117/12.2315773

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