26 April 2018 Experimental modeling of local laser hyperthermia using thermosensitive nanoparticles absorbing in NIR
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Abstract
In this work we investigated the use of composite crystalline core/shell nanoparticles LaF3:Nd3+(1%)@DyPO4 for fluorescence-based contactless thermometry, as well as laser-induced hyperthermia effect in optical model of biological tissue with modeled neoplasm. In preparation for this, a thermal calibration of the nanoparticles luminescence spectra was carried out. The results of the spectroscopic temperature measurement were compared to infrared thermal camera measurements. It showed that there is a significant difference between temperature recorded with IR camera and the actual temperature of the nanoparticles in the depth of the tissue model. The temperature calculated using the spectral method was up to 10 °C higher.
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Igor D. Romanishkin, Pavel V. Grachev, Daria V. Pominova, Ivan A. Burmistrov, Ilmo Sildos, Alexander S. Vanetsev, Elena O. Orlovskaya, Yuri V. Orlovskii, Victor B. Loschenov, Anastasia V. Ryabova, "Experimental modeling of local laser hyperthermia using thermosensitive nanoparticles absorbing in NIR", Proc. SPIE 10716, Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX, 107161C (26 April 2018); doi: 10.1117/12.2309459; https://doi.org/10.1117/12.2309459
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