Modification of polyelectrolyte microcapsules into a container for the low molecular weight compounds

O. A. Goryacheva; H. Gao; G. B. Sukhorukov

doi:10.1117/12.2314728

26 April 2018 Modification of polyelectrolyte microcapsules into a container for the low molecular weight compounds

O. A. Goryacheva, H. Gao, G. B. Sukhorukov

Proceedings Volume 10716, Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX; 107161W (2018) https://doi.org/10.1117/12.2314728
Event: Saratov Fall Meeting 2017, 2017, Saratov, Russian Federation

Abstract

Polyelectrolyte microcapsules are one of the most successful developments in the direction of target drug delivery. Nevertheless, to encapsulate low molecular weight compounds and to deliver the targeted drugs it is necessary to modify the surface of the microcapsules. Silica nanostructures obtained as result of hydrolysis of (3-Aminopropyl)- triethoxysilane (APTES) were used for the modification of the microcapsules. This material shows no toxic effect on cells and is capable of biodegradation. Amino-groups in the structure of APTES make it possible for further direct bioconjugation.

Citation Download Citation

O. A. Goryacheva, H. Gao, and G. B. Sukhorukov "Modification of polyelectrolyte microcapsules into a container for the low molecular weight compounds ", Proc. SPIE 10716, Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX, 107161W (26 April 2018); https://doi.org/10.1117/12.2314728

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