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26 April 2018 The lymphatic mechanisms of brain cleaning: application of optical coherence tomography and fluorescence microscopy
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Abstract
Here we studied the role of cerebral lymphatic system in the brain clearing using intraparenchymal injection of Evans Blue and gold nanorods assessed by optical coherent tomography and fluorescence microscopy. Our data clearly show that the cerebral lymphatic system plays an important role in the brain cleaning via meningeal lymphatic vessels but not cerebral veins. Meningeal lymphatic vessels transport fluid from the brain into the deep cervical node, which is the first anatomical “station” for lymph outflow from the brain. The lymphatic processes underlying brain clearing are more slowly vs. peripheral lymphatics. These results shed light on the lymphatic mechanisms responsible for brain clearing as well as interaction between the intra- and extracranial lymphatic compartment.
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O. Glushkovskaya-Semyachkina, A. Abdurashitov, I. Fedosov, A. Namykin, A. Pavlov, A. Shirokov, N. Shushunova, O. Sindeeva, A. Khorovodov, M. Ulanova, V. Sagatova, I. Agranovich, A. Bodrova, and J. Kurths "The lymphatic mechanisms of brain cleaning: application of optical coherence tomography and fluorescence microscopy", Proc. SPIE 10717, Saratov Fall Meeting 2017: Laser Physics and Photonics XVIII; and Computational Biophysics and Analysis of Biomedical Data IV, 107171V (26 April 2018); https://doi.org/10.1117/12.2315199
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