26 April 2018 Dynamical mechanisms of conducted vasoreactivity: minimalistic modeling study
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Abstract
Endothelial cells are cells lining the inner surface of the blood and lymphatic vessels, they separate the bloodstream from the deeper layers of the vascular wall. Earlier endothelium was considered only as a passive barrier between blood and tissues. However, it has now become apparent that endothelial cells, specifically reacting to different molecular signals generated locally and remotely, perform a variety of functions. Simulation of large vascular networks requires the development of specialized models of autoregulation of vascular tone. On the one hand, such models should have a strong support for cellular dynamics, on the other - be as computationally efficient as possible. A model of a two-dimensional cylindrical array of endothelial cells is proposed on the basis of the integral description by means of the whole-cell CVC. The process of propagation of hyperpolarizing and depolarizing pulses is investigated depending on the statistics of cell distribution between the two main types. Endothelial cells are considered as a dynamic system possessing bistability. Based on the articles, the results of the distribution of the resting-potential values were repeated, the propagation of the hyperpolarizing pulse was observed, the endothelial cell chain supported the propagation of the wave switching to a hyperpolarized state, and then the return wave returned to its original state.
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Ekaterina A. Kuryshova, Ekaterina A. Kuryshova, Kristina V. Rogatina, Kristina V. Rogatina, Dmitry E. Postnov, Dmitry E. Postnov, } "Dynamical mechanisms of conducted vasoreactivity: minimalistic modeling study", Proc. SPIE 10717, Saratov Fall Meeting 2017: Laser Physics and Photonics XVIII; and Computational Biophysics and Analysis of Biomedical Data IV, 1071721 (26 April 2018); doi: 10.1117/12.2315193; https://doi.org/10.1117/12.2315193
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