Lesion assessment and radiation dose in contrast-enhanced digital breast tomosynthesis

Hailiang Huang; David A. Scaduto; Chunling Liu; Jie Yang; Chencan Zhu; Kim Rinaldi; Jason Eisenberg; Jingxuan Liu; Mathias Hoernig; Julia Wicklein; Sebastian Vogt; Thomas Mertelmeier; Paul R. Fisher; Wei Zhao

doi:10.1117/12.2316371

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6 July 2018 Lesion assessment and radiation dose in contrast-enhanced digital breast tomosynthesis

Hailiang Huang, David A. Scaduto, Chunling Liu, Jie Yang, Chencan Zhu, Kim Rinaldi, Jason Eisenberg, Jingxuan Liu, Mathias Hoernig, Julia Wicklein, Sebastian Vogt, Thomas Mertelmeier, Paul R. Fisher, Wei Zhao

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Proceedings Volume 10718, 14th International Workshop on Breast Imaging (IWBI 2018); 107181J (2018) https://doi.org/10.1117/12.2316371
Event: The Fourteenth International Workshop on Breast Imaging, 2018, Atlanta, Georgia, United States

Abstract

Contrast-Enhanced Digital Breast Tomosynthesis (CEDBT) provides a three-dimensional (3D) contrast-enhancement map with co-registered anatomical information from low-energy DBT. It combines the benefits from Contrast-Enhanced Digital Mammography (CEDM) and Digital Breast Tomosynthesis (DBT), and may improve breast cancer detection and assessment of lesion morphology. We investigate the efficacy of CEDBT in the assessment of lesion contrast enhancement and margin identification, and evaluate the dose efficiency. We generate synthetic CEDM images from CEDBT data, similar to synthesis of 2D mammograms from DBT data, which may facilitate overall lesion assessment without additional radiation dose. Preliminary results from a patient study show that CEDBT depicts lesion margins better compared to CEDM, while the contrast-enhancement level for in-plane slice is not as high as in CEDM. CEDBT delivers less radiation dose compared to CEDM + DBT. Synthetic CEDM is able to provide lesion contrast-enhancement level comparable to CEDM.

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Hailiang Huang, David A. Scaduto, Chunling Liu, Jie Yang, Chencan Zhu, Kim Rinaldi, Jason Eisenberg, Jingxuan Liu, Mathias Hoernig, Julia Wicklein, Sebastian Vogt, Thomas Mertelmeier, Paul R. Fisher, and Wei Zhao "Lesion assessment and radiation dose in contrast-enhanced digital breast tomosynthesis", Proc. SPIE 10718, 14th International Workshop on Breast Imaging (IWBI 2018), 107181J (6 July 2018); https://doi.org/10.1117/12.2316371

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