Controllable particle hopping in optofluidic lattice for antibody screening and binding efficiency measurement

Y. Z. Shi; S. Xiong; Y. Zhang; L. K. Chin; J. H. Wu; T. N. Chen; A. Q. Liu

doi:10.1117/12.2319693

7 September 2018 Controllable particle hopping in optofluidic lattice for antibody screening and binding efficiency measurement

Y. Z. Shi, S. Xiong, Y. Zhang, L. K. Chin, J. H. Wu, T. N. Chen, A. Q. Liu

Author Affiliations +

Proceedings Volume 10723, Optical Trapping and Optical Micromanipulation XV; 107231Y (2018) https://doi.org/10.1117/12.2319693
Event: SPIE Nanoscience + Engineering, 2018, San Diego, California, United States

Abstract

Particle patterning and hopping has attracted much attention owing to their extensive involvement in many physical and biological studies. Here, by configuring an intriguing Optofluidic, we are able to pattern 500 nm particles into a 2D array in the flow stream. We also achieve a 2D patterning of cryptosporidium in the microchannel. By investing particle-particle interactions, we studies the long ignored new particle hopping mechanisms, and used them to screen antibodies. Our observed particle hopping in the flow stream completes the family of particle kinetics in optofluidic potential wells and inspires new minds in the develop new light fields in the microchannel. The 2D patterning of particles facilites the parallel culture and study of multiple biological samples in the flow stream.

Conference Presentation

Citation Download Citation

Y. Z. Shi, S. Xiong, Y. Zhang, L. K. Chin, J. H. Wu, T. N. Chen, and A. Q. Liu "Controllable particle hopping in optofluidic lattice for antibody screening and binding efficiency measurement", Proc. SPIE 10723, Optical Trapping and Optical Micromanipulation XV, 107231Y (7 September 2018); https://doi.org/10.1117/12.2319693

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