The paper aims to study the criteria of harmony by example of protective coloration for antelopes and dynamics of the parameters for human cardiovascular system at different stages of obesity. The criteria of harmony reflecting the adaptive mechanisms of the biological objects under consideration are obtained. In the case of antelopes (Taurotragus oryx), criteria of harmony chosen were colorimetric parameters of protective coloration, subjected to change due to the domestication of these animals. In the case of the human cardiovascular system, the parameters of heart rate, systolic blood pressure and diastolic blood pressure were selected. The results of the simulation show that the increase in body weight, due to hypodynamia in women, leads to a deterioration of the harmony of the dynamics of the cardiovascular system. As a criterion of harmony, the variety of combinations of values observed in the cycle of changes of these parameters built in the result of modeling is used. A similar dependence takes place in the example of protective coloration of antelopes. As a criterion of harmony, in this case, a variety of combinations of colorimetric parameters of the protective color of antelopes is used. The results of mathematical modeling obtained in the work allow us to propose a new approach to finding a universal criterion of harmony of living systems related to biodiversity and adaptation to living conditions.