We present some recent developments using smart optical tools, such as optical fiber tweezers (OFTs) and plasmonic optical antennas, to explore the biological world. Using OFTs, which act as a smart light touch, we realized the stable trapping and flexible manipulation of single particles, bacteria, and cells. The trapping and multifunctional manipulation is demonstrated using different samples varying from mammalian cells to bacteria, nanotubes and to biomolecules, with sizes changing from several tens of micrometer to a few nanometer. The OFTs is also used for the stable trapping and patterning of multiple particles and cells, with the ability of biophotonic waveguides formation based on bacteria. In addition to the trapping and manipulation of cell individuals, we also demonstrated that smart optical tools, such as plasmonic optical antennas, are capable of cellular exploration.
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