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6 December 2018 Polymeric micelles deliver phthalocyanine for enhancement in vitro photodynamic efficacy
Kuizhi Chen, Ruotao Guo, Shuanghuang Xiao, Qiaohao Ye, Hongqin Yang, Yiru Peng
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Proceedings Volume 10816, Advanced Optical Imaging Technologies; 108161M (2018) https://doi.org/10.1117/12.2501228
Event: SPIE/COS Photonics Asia, 2018, Beijing, China
Abstract
A novel polymeric nanoparticle was developed between the negatively charged dendrimer phthalocyanine and positively triblock copolymer for the use as an effective photosensitizer in photodynamic therapy. The intracellular uptake of dendrimer phthalocyanines in HeLa cell was significantly enhanced by encapsulated into nanoparticles. The photocytotoxicity of dendrimer phthalocyanines incorporated into polymeric micelles was also increased. The presence of nanoparticles located induced efficient cell death.
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Kuizhi Chen, Ruotao Guo, Shuanghuang Xiao, Qiaohao Ye, Hongqin Yang, and Yiru Peng "Polymeric micelles deliver phthalocyanine for enhancement in vitro photodynamic efficacy", Proc. SPIE 10816, Advanced Optical Imaging Technologies, 108161M (6 December 2018); https://doi.org/10.1117/12.2501228
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KEYWORDS
Photodynamic therapy
Nanoparticles
Dendrimers
Polymers
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