Cellular phase observations and measurements on red blood cells affected by lithium and lead ions with quantitative interferometric microscopy

Qi Wei; Zhilong Jiang; Yan Kong; Keding Yan; Liang Xue; Cheng Liu; Shouyu Wang

doi:10.1117/12.2500573

23 October 2018 Cellular phase observations and measurements on red blood cells affected by lithium and lead ions with quantitative interferometric microscopy

Qi Wei, Zhilong Jiang, Yan Kong, Keding Yan, Liang Xue, Cheng Liu, Shouyu Wang

Author Affiliations +

Proceedings Volume 10820, Optics in Health Care and Biomedical Optics VIII; 108201J (2018) https://doi.org/10.1117/12.2500573
Event: SPIE/COS Photonics Asia, 2018, Beijing, China

Abstract

As an important marker in disease diagnosis, red blood cell morphology measurement is necessary in biological and medical fields. However, traditional setups as microscopes and cytometers cannot provide enough quantitative information in morphology detections. In order to capture tiny variations of red blood cells affected by metal ions in external environment, quantitative interferometric microscopy is applied: combining with phase retrieval and cell recognition, cellular phases as well as additional quantitative cellular parameters can be acquired automatically and accurately. The research proves that quantitative interferometric microscopy can be potentially applied in cellular observations and measurements for both biological and medical applications.

Citation Download Citation

Qi Wei, Zhilong Jiang, Yan Kong, Keding Yan, Liang Xue, Cheng Liu, and Shouyu Wang "Cellular phase observations and measurements on red blood cells affected by lithium and lead ions with quantitative interferometric microscopy", Proc. SPIE 10820, Optics in Health Care and Biomedical Optics VIII, 108201J (23 October 2018); https://doi.org/10.1117/12.2500573

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