In-line taper fiber-optic interferometer and FBG for label-free detection of cancer biomarker

Dandan Sun

doi:10.1117/12.2500697

23 October 2018 In-line taper fiber-optic interferometer and FBG for label-free detection of cancer biomarker

Dandan Sun

Proceedings Volume 10820, Optics in Health Care and Biomedical Optics VIII; 108201W (2018) https://doi.org/10.1117/12.2500697
Event: SPIE/COS Photonics Asia, 2018, Beijing, China

Abstract

A taper interferometer embedded in fiber Bragg grating (FBG) is proposed and experimentally demonstrated for labelfree detection of breast cancer biomarker (HER2). The tapered fiber-optic interferometer sensor is extremely sensitive to ambient refractive index (RI) and the resonant wavelength of FBG is essentially insensitive to the RI variation. The FBG can be applied as a temperature thermometer, which monitoring the undesired drifts due to its independent response to the temperature. The label-free bio-recognition scheme is achieved by the covalent immobilization method for conjugation with HER2 antibody to achieve target biomarker specific detection. The proposed sensor presents a low limit-of-detection (LOD) of 5 ng/mL, providing a platform for the application in early diagnosis on the breast cancer.

Citation Download Citation

Dandan Sun "In-line taper fiber-optic interferometer and FBG for label-free detection of cancer biomarker ", Proc. SPIE 10820, Optics in Health Care and Biomedical Optics VIII, 108201W (23 October 2018); https://doi.org/10.1117/12.2500697

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
6 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Fiber Bragg gratings

Interferometers

Fiber optics

Sensors

Cancer

Fiber optics sensors

Biosensors

Show All Keywords

Keywords/Phrases

Search In:

Publication Years