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23 October 2018 In-line taper fiber-optic interferometer and FBG for label-free detection of cancer biomarker
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Abstract
A taper interferometer embedded in fiber Bragg grating (FBG) is proposed and experimentally demonstrated for labelfree detection of breast cancer biomarker (HER2). The tapered fiber-optic interferometer sensor is extremely sensitive to ambient refractive index (RI) and the resonant wavelength of FBG is essentially insensitive to the RI variation. The FBG can be applied as a temperature thermometer, which monitoring the undesired drifts due to its independent response to the temperature. The label-free bio-recognition scheme is achieved by the covalent immobilization method for conjugation with HER2 antibody to achieve target biomarker specific detection. The proposed sensor presents a low limit-of-detection (LOD) of 5 ng/mL, providing a platform for the application in early diagnosis on the breast cancer.
© (2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Dandan Sun "In-line taper fiber-optic interferometer and FBG for label-free detection of cancer biomarker ", Proc. SPIE 10820, Optics in Health Care and Biomedical Optics VIII, 108201W (23 October 2018); https://doi.org/10.1117/12.2500697
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