Label-free imaging using multimodal microscopy in vivo and in vitro

Jiuling Liao; Tingai Chen; Yufeng Gao; Ting Wu; Jia Yu; Xianyuan Xia; Wei Zheng

doi:10.1117/12.2502490

23 October 2018 Label-free imaging using multimodal microscopy in vivo and in vitro

Jiuling Liao, Tingai Chen, Yufeng Gao, Ting Wu, Jia Yu, Xianyuan Xia, Wei Zheng

Proceedings Volume 10820, Optics in Health Care and Biomedical Optics VIII; 108203D (2018) https://doi.org/10.1117/12.2502490
Event: SPIE/COS Photonics Asia, 2018, Beijing, China

Abstract

Many imaging technologies, such as two photon microscopy (TPM), second generation microscopy (SHG) and photoacoustic microscopy (PAM), have successfully demonstrated the ability to extract anatomical, functional and molecular information of biological samples. However, they always fail to obtain comprehensive information from biological tissue due to single imaging modality. To address this limitation, we developed a multimodal microscopy with fully integrated PAM, TPM and SHG. The home-built multimodal microscopy system enable label-free imaging of biomedical tissue with sub-micron resolution in vivo and in vitro. The results may offer a new tool to provide the capable of fast comprehensive information capturing for biological studies.

Citation Download Citation

Jiuling Liao, Tingai Chen, Yufeng Gao, Ting Wu, Jia Yu, Xianyuan Xia, and Wei Zheng "Label-free imaging using multimodal microscopy in vivo and in vitro", Proc. SPIE 10820, Optics in Health Care and Biomedical Optics VIII, 108203D (23 October 2018); https://doi.org/10.1117/12.2502490

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KEYWORDS

Second-harmonic generation

Microscopy

In vivo imaging

In vitro testing

Multimodal imaging

Photoacoustic spectroscopy

Tissues

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