Label-free DNA detection based on whispering gallery mode optofluidic microcavity biosensor

Liang Fu; Xiaogang Chen; Qijing Lu; Shunsen Xie

doi:10.1117/12.2501139

25 October 2018 Label-free DNA detection based on whispering gallery mode optofluidic microcavity biosensor

Liang Fu, Xiaogang Chen, Qijing Lu, Shunsen Xie

Proceedings Volume 10823, Nanophotonics and Micro/Nano Optics IV; 108231E (2018) https://doi.org/10.1117/12.2501139
Event: SPIE/COS Photonics Asia, 2018, Beijing, China

Abstract

We proposed and experimentally demonstrated a sensitive, label-free, real-time and low-cost optofluidic microcavity biosensor for DNA detection. The change of whispering gallery mode (WGM) resonant wavelength is monitored by data acquisition card in real-time. The experimental results show that the biosensor can significantly distinguish the non-complementary single strand (ssDNA), single nucleotide mismatch ssDNA, and target ssDNA. In addition, a sensing mechanism based on WGM coupling depth was also experimentally demonstrated which would have potential for detection of biological and chemical analytes in the future.

Citation Download Citation

Liang Fu, Xiaogang Chen, Qijing Lu, and Shunsen Xie "Label-free DNA detection based on whispering gallery mode optofluidic microcavity biosensor", Proc. SPIE 10823, Nanophotonics and Micro/Nano Optics IV, 108231E (25 October 2018); https://doi.org/10.1117/12.2501139

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