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25 October 2018 Evaluation of free-radical scavenging and antioxidant activities of polydatin nanoethosomes
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Abstract
Cellular damage induced by free-radicals like reactive oxygen species has been implicated in several diseases. The ROS radicals like alkoxy radical(RO-) and peroxy radical (ROO-) are similar to those that are physiologically active and thus might initiate a cascade of intracellular toxic events leading to DNA damage and cell death. Hence naturally anti-oxidant play a vital role in combating these conditions. In this study, polydatin nanoethosomes (Pol-NE) was prepared by high pressure homogenization technique. The effects of Pol-NE on free radical scavenging and antioxidant was investigated. The particle size and zeta potential of Pol-NE was 96.1±4.5 nm and -17.31±1.67 mV, respectively. By free radical scavenging and antioxidant assays, the IC50 value of Pol-NE were 28.71, 9.83 μg/mL with DPPH, ABTS assay respectively, and 0.143 mg ferrous sulfate/1 mg Pol-NE with FRAP assay. These results indicated that the antioxidant properties of Pol-NE hold great potential used as an alternative to more toxic synthetic anti-oxidants as an additive in food, cosmetic and pharmaceutical preparations for the oxidative diseases treatment.
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Jia-zhen Du, Jia-Min Gao, Fan Shi, Tong-sheng Chen, Yi-fei Wang, and Zhi-ping Wang "Evaluation of free-radical scavenging and antioxidant activities of polydatin nanoethosomes", Proc. SPIE 10823, Nanophotonics and Micro/Nano Optics IV, 1082315 (25 October 2018); https://doi.org/10.1117/12.2500148
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