Pharmacokinetic biodistribution assessment of Phosphorescent sensor, PtG4 Oxyphor in mice for optimization of in vivo oxygenation imaging

Mengyu Jia; Jennifer R. Shell; Xu Cao; Jason R. Gunn; Sergei Vinogradov; Brian W. Pogue

doi:10.1117/12.2513220

8 April 2019 Pharmacokinetic biodistribution assessment of Phosphorescent sensor, PtG4 Oxyphor in mice for optimization of in vivo oxygenation imaging

Mengyu Jia, Jennifer R. Shell, Xu Cao, Jason R. Gunn, Sergei Vinogradov, Brian W. Pogue

Author Affiliations +

Proceedings Volume 10862, Molecular-Guided Surgery: Molecules, Devices, and Applications V; 108621H (2019) https://doi.org/10.1117/12.2513220
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Luminescence molecular tomography with Cherenkov excitation offers the ability to non-invasively image and quantify temporal changes in fluorescence throughout the body, and then further realize tumor localization. This can be done in radiotherapy to determine the response to treatment in fractionated therapy. To obtain high signal-to-background or signal-to-noise ratio measurement, it is critical to know the best post time point of in-vivo agent-based molecular imaging, which could account on a high signal ratio of target to skin (TSR). For this purpose, ex-vivo murine experiments were performed to quantify the biokinetics and biodistribution of the major organs, plasma, tumor, and skin.

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Mengyu Jia, Jennifer R. Shell, Xu Cao, Jason R. Gunn, Sergei Vinogradov, and Brian W. Pogue "Pharmacokinetic biodistribution assessment of Phosphorescent sensor, PtG4 Oxyphor in mice for optimization of in vivo oxygenation imaging", Proc. SPIE 10862, Molecular-Guided Surgery: Molecules, Devices, and Applications V, 108621H (8 April 2019); https://doi.org/10.1117/12.2513220

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