Functional and multimodal photoacoustic microscopy for brain mapping and surgery

Donghyun Lee; Jongbeom Kim; Jin Young Kim; Jin woo Baik; Chulhong Kim

doi:10.1117/12.2507682

1 March 2019 Functional and multimodal photoacoustic microscopy for brain mapping and surgery

Donghyun Lee, Jongbeom Kim, Jin Young Kim, Jin woo Baik, Chulhong Kim

Proceedings Volume 10864, Clinical and Translational Neurophotonics 2019; 108640C (2019) https://doi.org/10.1117/12.2507682
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

The noninvasive imaging of a brain has led to significant advances for optical techniques in neurosurgery and brain imaging. Previous study reported hemodynamic brain activity is related with neuronal activity. Photoacoustic microscopy (PAM) can detect hemodynamic activity in blood vessels by exciting red blood cells so neuronal activity can be detected by imaging vessels with PAM. Based on the results, we observed the cortical response to electrical stimulations of mouse’s hindlimbs with our functional photoacoustic microscopy (FPAM) system. Especially, based on a fast-speed imaging capability of our FPAM system, we observed instantaneous changes of hemodynamic brain activity by imaging a mouse brain non-invasively with capillary-level resolution while electrically stimulating the mouse’s hindlimbs. For the future studies, the intraoperative surgical photoacoustic microscopy system can be used to monitor the cortical response to electrical stimulations. By integrating FPAM system with surgical microscopy, we developed an intraoperative surgical photoacoustic microscopy system that provides photoacoustic images and enlarged surface view simultaneously. Additionally, by back projecting the acquired photoacoustic images on the ocular lens of the surgical microscopy, surgeons can see both the enlarged surface view and photoacoustic images simultaneously without moving the sight from the ocular lens. Thus, the developed intraoperative surgical photoacoustic microscopy system can be a vital tool for the microsurgeries and neurosurgeries including monitoring the cortical response to electrical stimulations.

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Donghyun Lee, Jongbeom Kim, Jin Young Kim, Jin woo Baik, and Chulhong Kim "Functional and multimodal photoacoustic microscopy for brain mapping and surgery", Proc. SPIE 10864, Clinical and Translational Neurophotonics 2019, 108640C (1 March 2019); https://doi.org/10.1117/12.2507682

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KEYWORDS

Photoacoustic microscopy

Brain

Neuroimaging

Microscopes

Surgery

Photoacoustic spectroscopy

Hemodynamics

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