Functional near-infrared spectroscopy as a window to cardiovascular health

Elizabeth Lyde; Xinlong Wang; Hanli Liu; Kytai Nguyen; Paul Fadel; George Alexandrakis

doi:10.1117/12.2506658

1 March 2019 Functional near-infrared spectroscopy as a window to cardiovascular health

Elizabeth Lyde, Xinlong Wang, Hanli Liu, Kytai Nguyen, Paul Fadel, George Alexandrakis

Proceedings Volume 10864, Clinical and Translational Neurophotonics 2019; 108640U (2019) https://doi.org/10.1117/12.2506658
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

The temporal evolution of cortical activation patterns during a handgrip task inducing forearm muscle fatigue was studied with functional near-infrared spectroscopy (fNIRS). Brain activation patterns mapped over the prefrontal and sensorimotor cortices (111 channels) and concurrent fatigue measurements, assessed by a force sensor, were studied for a group of physical active subjects versus an age-matched healthy, but non-exercising group. Thirteen young adults (18-35 years old) were recruited who performed intermittent handgrip contractions for 3.5s alternating with 6.5s of rest for 120 blocks with their dominant hand. Observed differences in activation and connectivity in the primary motor cortex (M1), premotor and supplementary motor cortex (PMC/SMA), and prefrontal cortex (PFC) in both hemispheres hinted at differences in compensatory tactics used by the brain based on available physical resources that depend on physical activity. Furthermore, our study demonstrated strengthened FC throughout the entire duration of the fatigue-inducing handgrip task. Ultimately, this ongoing study will provide baseline measurements on the brain’s compensatory patterns for follow-up work on older individuals with impaired cardiovascular health performing the fatiguing handgrip task.

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Elizabeth Lyde, Xinlong Wang, Hanli Liu, Kytai Nguyen, Paul Fadel, and George Alexandrakis "Functional near-infrared spectroscopy as a window to cardiovascular health", Proc. SPIE 10864, Clinical and Translational Neurophotonics 2019, 108640U (1 March 2019); https://doi.org/10.1117/12.2506658

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KEYWORDS

Hemodynamics

Functional magnetic resonance imaging

Brain

Sensors

Cortical activation

Near infrared spectroscopy

Prefrontal cortex

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