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1 March 2019 Lymphatic clearance from the blood after subarachnoid hemorrhages
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Proceedings Volume 10865, Neural Imaging and Sensing 2019; 108650T (2019) https://doi.org/10.1117/12.2509065
Event: SPIE BiOS, 2019, San Francisco, California, United States
Abstract
Here we present preliminary experimental data suggesting about involvement of the meningeal and cervical lymphatics in neurorehabilitation. Using model of hemorrhagic stroke, immunohistochemical analysis and atomic absorption spectroscopy, we clearly demonstrate the lymphatic clearance from the blood after stroke via the meningeal lymphatic vessels with further accumulation of hemosiderin and iron (products of disaggregated hemoglobin) in the deep cervical node (dcLN). The optical coherent tomography (OCT) was used for in vivo monitoring of accumulation of gold nanorods (92 nm in diameter) in the dcLN after their injection into the cisterna magna with the aim of mimicking of the brain clearance from of blood. The both ex vivo and in vivo data show the lymphatic clearance from subjects (the blood/GNRs) injected into the subarachnoid space that might be an important mechanism of neurorehabilitation after the intracranial hemorrhages.
Conference Presentation
© (2019) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
O. Semyachkina-Glushkovskaya, A. Abdurashitov, A. Dubrovsky, A. Shirokov, N. Navolokin, M. Klimova, E. Duarte Torres, A. Khorovodov, A. Mamedova, A. E. Shareef, A. Terskov, E. Saranceva, T. Iskra, and J. Kurths "Lymphatic clearance from the blood after subarachnoid hemorrhages", Proc. SPIE 10865, Neural Imaging and Sensing 2019, 108650T (1 March 2019); https://doi.org/10.1117/12.2509065
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