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22 February 2019 Normalized field autocorrelation function-based optical coherence tomography 3D angiography
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Optical coherence tomography angiography (OCTA) has been widely used for en face visualization of vasculatures but challenged for real 3D topologic imaging due to the β€˜tail’ artifacts that appear below large vessel because of multiple scattered light within the vessel. We introduce a normalized field autocorrelation function-based OCTA (π’ˆπŸ-OCTA) which minimizes the projection artifacts and is capable of 3D topologic vasculature imaging. π’ˆπŸ(τ) is calculated from repeated OCT acquisitions for each spatial location. The largest decay of π’ˆπŸ(τ) is retrieved to represent the dynamics for each voxel. To account for the small π’ˆπŸ(τ) decay in capillaries where red blood cells (RBCs) are flowing slowly and discontinuously, Intralipid is injected to enhance the OCT signal. With the Intralipid-enhanced signal and shorter decorrelation time processing, we demonstrate that the proposed technique realized 3D OCTA with high signal-to-noise ratio and a negligible β€˜tail’ projection. In addition, compared to regular OCTA, the proposed π’ˆπŸ-OCTA doubles the imaging depth. By reducing β€˜tail’ artifacts, this technique provides a more accurate rendering of the vascular anatomy for more quantitative characterization of the vascular networks.
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Jianbo Tang, Sefik Evren Erdener, and David A. Boas "Normalized field autocorrelation function-based optical coherence tomography 3D angiography", Proc. SPIE 10867, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIII, 108672U (22 February 2019);

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