High-resolution chromophore concentration recovery using multi-wavelength photo-magnetic imaging

Maha Algarawi; Farouk Nouizi; Alex Luk; Mehrnaz Mehrabi; Hakan Erkol; Mehmet Burçin Ünlü; Gultekin Gulsen; Seunghoon Ha

doi:10.1117/12.2504310

27 February 2019 High-resolution chromophore concentration recovery using multi-wavelength photo-magnetic imaging

Maha Algarawi, Farouk Nouizi, Alex Luk, Mehrnaz Mehrabi, Hakan Erkol, Mehmet Burçin Ünlü, Gultekin Gulsen, Seunghoon Ha

Proceedings Volume 10871, Multimodal Biomedical Imaging XIV; 108710F (2019) https://doi.org/10.1117/12.2504310
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Although diffuse optical tomography (DOT) is able to obtain valuable functional information, its routine use in clinic is hampered by its poor spatial resolution and quantitative accuracy. Previously, our team introduced Photo-Magnetic Imaging (PMI) to overcome the limitation of DOT. PMI is a hybrid modality that synergistically utilizes optics and Magnetic Resonance Imaging (MRI). While illuminating the imaged medium by near-infrared laser, the induced internal temperature increase is measured using Magnetic Resonance Thermometry (MRT). Using these MRT maps, optical absorption maps at the laser's wavelength can be recovered using the dedicated PMI image reconstruction algorithm. In this paper, we present the result of the first validation simulation study of multi-wavelength PMI that utilizes five different laser wavelengths ranging between 760 and 980 nm. Using the high resolution wavelength specific absorption maps, PMI successfully recovered the concentration of three dyes, used as chromophore in the composition of our phantom, with high spatial resolution and quantitative accuracy. By providing functional information at high resolution, multi-wavelength PMI will be a valuable tool for monitoring tissue physiology, cancer detection and monitoring.

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Maha Algarawi, Farouk Nouizi, Alex Luk, Mehrnaz Mehrabi, Hakan Erkol, Mehmet Burçin Ünlü, Gultekin Gulsen, and Seunghoon Ha "High-resolution chromophore concentration recovery using multi-wavelength photo-magnetic imaging", Proc. SPIE 10871, Multimodal Biomedical Imaging XIV, 108710F (27 February 2019); https://doi.org/10.1117/12.2504310

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