Comparison of imaging and non-imaging based methods to determine the radiation profile of fiber diffusers for photodynamic therapy (Conference Presentation)

Stephan Stroebl; Matthias Domke; Tilmann Trebst; Ronald Sroka

doi:10.1117/12.2508384

4 March 2019 Comparison of imaging and non-imaging based methods to determine the radiation profile of fiber diffusers for photodynamic therapy (Conference Presentation)

Stephan Stroebl, Matthias Domke, Tilmann Trebst, Ronald Sroka

Author Affiliations +

Proceedings Volume 10872, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIX; 1087216 (2019) https://doi.org/10.1117/12.2508384
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Photodynamic therapy is a promising method to selectively treat cancer with light. Therefore, the tumour cells have to be illuminated homogeneously by distributing optical fibers with diffuser tips within the tumour tissue. The challenge is to measure and thereby, tailor the irradiation of the diffusers. In this paper, a novel non-imaging, camera-based method to measure the radiation profile is introduced and compared to an established imaging-based method. The radiation profile of a commercial polymer diffuser with radial homogeneous emittance and the profile of an ultrafast-laser surface structured fiber with radially asymmetric emission was evaluated. For the novel method, the diffuser was positioned in close contact to the image sensor. After coupling a LED to the diffuser, images were recorded for various radial positions. The irradiation profiles of the diffusers were also determined using an imaging camera system. The radiation profiles measured with the novel approach stand in good agreement with the existing imaging method using radial homogeneously emitting diffusers. However, the comparison revealed that the novel approach is advantageous, if the radiation profile is radially asymmetric and if the near-field is of special interest. In this case, several details, such as double peaks, were resolved, which were invisible using other methods. The novel approach is of special interest for the development of simulation models to gain further knowledge about the laser-tissue interaction in the near-field of the fiber. Thereby, irradiation profiles of diffusers could be predicted and tailored towards an application specific irradiation.

Conference Presentation

Citation Download Citation

Stephan Stroebl, Matthias Domke, Tilmann Trebst, and Ronald Sroka "Comparison of imaging and non-imaging based methods to determine the radiation profile of fiber diffusers for photodynamic therapy (Conference Presentation)", Proc. SPIE 10872, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIX, 1087216 (4 March 2019); https://doi.org/10.1117/12.2508384

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Diffusers

Photodynamic therapy

Cameras

Imaging systems

Near field

Cancer

Optical fibers

Show All Keywords

Keywords/Phrases

Search In:

Publication Years