Functional vascular imaging by Photoacoustic Microscopy (PAM) and its biomedical application

Renzhe Bi; Ghayathri Balasundaram; Dinish U.S.; Seungwan Jeon; Toru Imai; Yang Pu; Lai Guan Ng; Chulhong Kim; Lihong Wang; Malini Olivo

doi:10.1117/12.2507355

4 March 2019 Functional vascular imaging by Photoacoustic Microscopy (PAM) and its biomedical application

Renzhe Bi, Ghayathri Balasundaram, Dinish U.S., Seungwan Jeon, Toru Imai, Yang Pu, Lai Guan Ng, Chulhong Kim, Lihong Wang, Malini Olivo

Author Affiliations +

Proceedings Volume 10873, Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis; 108730B (2019) https://doi.org/10.1117/12.2507355
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

The hemodynamics and oxygen saturation status of vascular are very important biomarkers for disease, such as brain glioma tumor and ischemia-reperfusion ulcer. Therefore, a high spatial resolution imaging tool for vascular imaging is demanded. Conventional optical imaging modalities, including confocal microscopy and two-photon microscopy, require external contrast agent to image blood vessels and are not sensitive to oxygen saturation. The development of photoacoustic microscopy provides a contrast-free, high-spatial resolution and functional vascular imaging tool. It’s gaining more and more popularity in biomedical research. In this paper, we introduce a dual-wavelength opticalresolution photoacoustic microscopy (OR-PAM) system for functional imaging of vasculature. This system has demonstrated its application in brain glioma tumor imaging, as well as skin ischemia-reperfusion imaging.

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Citation Download Citation

Renzhe Bi, Ghayathri Balasundaram, Dinish U.S., Seungwan Jeon, Toru Imai, Yang Pu, Lai Guan Ng, Chulhong Kim, Lihong Wang, and Malini Olivo "Functional vascular imaging by Photoacoustic Microscopy (PAM) and its biomedical application", Proc. SPIE 10873, Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 108730B (4 March 2019); https://doi.org/10.1117/12.2507355

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