Monitoring total hemoglobin concentration changes across neoadjuvant chemotherapy in PgR-positive and PgR-negative breast cancer with diffuse optical tomography

Mirella L. Altoe; Alessandro Marone; Hyun K. Kim; Mariella Tejada; Hanina Hibshoosh; Katherine Crew; Kevin Kalinsky; Dawn L. Hershman; Andreas H. Hielscher

doi:10.1117/12.2510172

1 March 2019 Monitoring total hemoglobin concentration changes across neoadjuvant chemotherapy in PgR-positive and PgR-negative breast cancer with diffuse optical tomography

Mirella L. Altoe, Alessandro Marone, Hyun K. Kim, Mariella Tejada, Hanina Hibshoosh, Katherine Crew, Kevin Kalinsky, Dawn L. Hershman, Andreas H. Hielscher

Author Affiliations +

Proceedings Volume 10874, Optical Tomography and Spectroscopy of Tissue XIII; 108741L (2019) https://doi.org/10.1117/12.2510172
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

The aim of this study was to investigate the optical chemotherapy changes induced by neoadjuvant chemotherapy (NAC) in PgR-positive and PgR-negative breast cancer subtypes using a diffuse optical tomographic breast imaging system (DOTBIS). ctTHb reduction in the tumor volume was greater for patients with PgR-negative, a statistically significant difference of 48.91μM, p = .022, which suggest that PgR-negative tumors are generally less resistant to NAC. These observations indicate that PgR negativity may be combined to optically derived biomarkers for predicting pCR during neoadjuvant chemotherapy.

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Mirella L. Altoe, Alessandro Marone, Hyun K. Kim, Mariella Tejada, Hanina Hibshoosh, Katherine Crew, Kevin Kalinsky, Dawn L. Hershman, and Andreas H. Hielscher "Monitoring total hemoglobin concentration changes across neoadjuvant chemotherapy in PgR-positive and PgR-negative breast cancer with diffuse optical tomography", Proc. SPIE 10874, Optical Tomography and Spectroscopy of Tissue XIII, 108741L (1 March 2019); https://doi.org/10.1117/12.2510172

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