A multi-wavelength single-pixel SFD imaging system based on lock-in photon-counting detection

Xi Hou; Tongxin Li; Kuanxin Zhao; Mai Dan; Feng Gao

doi:10.1117/12.2507406

1 March 2019 A multi-wavelength single-pixel SFD imaging system based on lock-in photon-counting detection

Xi Hou, Tongxin Li, Kuanxin Zhao, Mai Dan, Feng Gao

Proceedings Volume 10874, Optical Tomography and Spectroscopy of Tissue XIII; 108741V (2019) https://doi.org/10.1117/12.2507406
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Spatial frequency domain (SFD) imaging offers a wide-field modality to effectively characterize the optical properties (absorption and scattering coefficients), and furthermore to calculate the chromophore concentrations from multiwavelength measurements, in biological tissues. Previous SFD imaging systems mostly capture the two-dimensional reflected light using an expensive charge-coupled device camera that requires switching between the multi-wavelength collections. With recent proliferation in low-cost and technology we present herein a highly-sensitive novel single-pixel SFD imaging system for simultaneous and acquisition of multi-wavelength images. In the approach, three LED-sources at 455-nm, 530-nm and 660-nm wavelengths are temporally modulated at different frequencies, and all focused to the first digital micromirror device (DMD) to generate a wide-field sinusoidal illumination on tissues. The reflected signal is spatially integrated by the second DMD that is coded according to the transform matrix, and fed into a lock-in photoncounting module and temporally demodulated to extract the signals at each wavelength. The SFD images at each wavelength are recovered by single-pixel imaging algorithm, respectively, and then used to calculate the modulation transfer function for extraction of the optical properties. The proposed system is experimentally validated on phantoms, demonstrating the system stability, measurement linearity, negligible inter-wavelength crosstalk, and recovery effectiveness.

Citation Download Citation

Xi Hou, Tongxin Li, Kuanxin Zhao, Mai Dan, and Feng Gao "A multi-wavelength single-pixel SFD imaging system based on lock-in photon-counting detection", Proc. SPIE 10874, Optical Tomography and Spectroscopy of Tissue XIII, 108741V (1 March 2019); https://doi.org/10.1117/12.2507406

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KEYWORDS

Modulation

Imaging systems

Signal detection

Tissues

Absorption

Modulation transfer functions

Optical properties

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