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4 March 2019 Laser-induced liquid micro-jets for needle-free injection into biological tissue (Conference Presentation)
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Abstract
Fast liquid jets (<150 m/s) are used as a needle-free fluid injection into elastomeric tissue such as skin. Because the fluid droplets are smaller than a typical needle diameter, there is less collateral damage caused by the jets in the intervened body. In this study, we aim to investigate the potential of the method to deliver liquids into biological tissues with higher stiffness than skin. To address this challenge we have implemented an optofluidic jetting system capable of generating supersonic liquid microjets driven by laser cavitation. Considering microfluidic properties of the system, we have exceeded a method to produce jets in a repetitive regime with rates of up to 6 Hz, diameters of 10, 15 and 30 µm and velocities exceeding 550 m/s. We have characterized the injection depth with respect to jet speed, jet diameter and elastic modulus of the sample material. Experiments were performed on hydrogels with Young’s modulus from 8 kPa to 1 MPa, which covers the wide spectrum of biological elastomers like inner body organ tissues, blood vessels, skin or cartilage.
Conference Presentation
© (2019) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Jan Krizek, Paul Delrot, and Christophe Moser "Laser-induced liquid micro-jets for needle-free injection into biological tissue (Conference Presentation)", Proc. SPIE 10875, Microfluidics, BioMEMS, and Medical Microsystems XVII, 1087512 (4 March 2019); https://doi.org/10.1117/12.2509555
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