Polarized light Monte Carlo simulation of cervical collagen ultrastructure (Conference Presentation)

Joseph Chue-Sang; Jessica C. Ramella-Roman

doi:10.1117/12.2508611

4 March 2019 Polarized light Monte Carlo simulation of cervical collagen ultrastructure (Conference Presentation)

Joseph Chue-Sang, Jessica C. Ramella-Roman

Proceedings Volume 10876, Optical Interactions with Tissue and Cells XXX; 108760P (2019) https://doi.org/10.1117/12.2508611
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Polarized light microscopy and polarimetry has been used to assess changes in cervical structure by targeting its collagen. 75% of the human cervix is in fact composed of highly arranged collagen which is birefringent. Recently we have used Mueller Matrix polarimetry to image the human cervix in-vivo to determine loss of collagen arrangement associated with later stages of pregnancy. In an effort to improve our system capability and better determine the provenance of the polarized signal we have developed a Polarized Light Monte Carlo model capable of characterizing polarized light interaction with a birefringent, scattering, and absorbing medium such as the cervix. We have utilized this model to investigate the effect of cervical collagen arrangement typical of late stage in pregnancy on polarized light. In this talk we will illustrate the model framework, its validations, and provide several test cases in model cervices.

Conference Presentation

Citation Download Citation

Joseph Chue-Sang and Jessica C. Ramella-Roman "Polarized light Monte Carlo simulation of cervical collagen ultrastructure (Conference Presentation)", Proc. SPIE 10876, Optical Interactions with Tissue and Cells XXX, 108760P (4 March 2019); https://doi.org/10.1117/12.2508611

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available