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4 March 2019 Polarized light Monte Carlo simulation of cervical collagen ultrastructure (Conference Presentation)
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Abstract
Polarized light microscopy and polarimetry has been used to assess changes in cervical structure by targeting its collagen. 75% of the human cervix is in fact composed of highly arranged collagen which is birefringent. Recently we have used Mueller Matrix polarimetry to image the human cervix in-vivo to determine loss of collagen arrangement associated with later stages of pregnancy. In an effort to improve our system capability and better determine the provenance of the polarized signal we have developed a Polarized Light Monte Carlo model capable of characterizing polarized light interaction with a birefringent, scattering, and absorbing medium such as the cervix. We have utilized this model to investigate the effect of cervical collagen arrangement typical of late stage in pregnancy on polarized light. In this talk we will illustrate the model framework, its validations, and provide several test cases in model cervices.
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Joseph Chue-Sang and Jessica C. Ramella-Roman "Polarized light Monte Carlo simulation of cervical collagen ultrastructure (Conference Presentation)", Proc. SPIE 10876, Optical Interactions with Tissue and Cells XXX, 108760P (4 March 2019); https://doi.org/10.1117/12.2508611
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