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4 March 2019 Monitoring cerebral and cutaneous hemodynamics through in vivo skull and skin optical clearing techniques (Conference Presentation)
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In vivo monitoring cerebral and cutaneous hemodynamics is of great important to investigate brain and peripheral circulation system functional responses to physiopathologic stimulations. Nevertheless, the high scattering characteristics of skull and skin severely limit optical imaging performance. Fortunately, in vivo tissue optical clearing techniques can efficiently overcome these problem. In this work, we combined hyperspectral imaging (HSI) and laser speckle contrast imaging (LSCI) to simultaneously monitor the changes in cortical and cutaneous microvascular blood oxygen saturation and blood flow under assistance of in vivo skull and skin optical clearing techniques, and quantitatively compared the difference between cerebral and cutaneous arteriovenous functional responses when the hypoxic stimulations was performed. The results show that the cerebral arteriovenous blood flow response is much more sensitive to the hypoxic stimulations comparing with that of cutaneous vessels. As for the arteriovenous blood oxygen response, there are only small differences between cerebral and cutaneous vessels to the instant hypoxia, but the blood oxygen level of cerebral vessels recovers faster than that of cutaneous vessels after the hypoxic stimulation. This work provides a feasible solution to realize visualization of in vivo monitoring cerebral and cutaneous microvascular reactivity with minimal invasiveness. Monitoring of microvascular reactivity with high resolution is of great significance to the study of vascular dysfunction in some peripheral vascular and cerebrovascular diseases.
Conference Presentation
© (2019) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Wei Feng, Chao Zhang, and Dan Zhu "Monitoring cerebral and cutaneous hemodynamics through in vivo skull and skin optical clearing techniques (Conference Presentation)", Proc. SPIE 10877, Dynamics and Fluctuations in Biomedical Photonics XVI, 108770O (4 March 2019);

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