Ultracompact high resolution photoacoustic microscopy of hemorrhagic shock

Qian Chen; Lei Xi

doi:10.1117/12.2506218

27 February 2019 Ultracompact high resolution photoacoustic microscopy of hemorrhagic shock

Qian Chen, Lei Xi

Proceedings Volume 10878, Photons Plus Ultrasound: Imaging and Sensing 2019; 108782Z (2019) https://doi.org/10.1117/12.2506218
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Hemorrhagic shock, as an important clinical issue, is regarding as a critical disease with a high mortality rate. Unfortunately, existing clinical technologies are inaccessible to assess the hemorrhagic shock via hemodynamics in microcirculation. Here, we proposed an ultracompact photoacoustic microscope to assess hemorrhagic shock by using a rat model. In animal study, hemodynamic features of the microvascular network including concentration of total hemoglobin (C_HbT) and small vascular density (SVD) were derived to assess the microvascular hemodynamics of different organs, assessing the hemorrhagic shock via microcirculation. On the other hand, in vivo oral imaging of healthy volunteers also indicates the translational possibility of this technique for clinical evaluation of hemorrhagic shock.

Citation Download Citation

Qian Chen and Lei Xi "Ultracompact high resolution photoacoustic microscopy of hemorrhagic shock", Proc. SPIE 10878, Photons Plus Ultrasound: Imaging and Sensing 2019, 108782Z (27 February 2019); https://doi.org/10.1117/12.2506218

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