Nonlinear photoacoustic generation by pump-probe excitation

Fei Cao; Zhihai Qiu; Kinfung Wong; Puxiang Lai; Lei Sun

doi:10.1117/12.2507342

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27 February 2019 Nonlinear photoacoustic generation by pump-probe excitation

Fei Cao, Zhihai Qiu, Kinfung Wong, Puxiang Lai, Lei Sun

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Proceedings Volume 10878, Photons Plus Ultrasound: Imaging and Sensing 2019; 108784R (2019) https://doi.org/10.1117/12.2507342
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Photoacoustic technique has undergone major developments in recent decades. Most of current photoacoustic systems work in the linear range, in which the photoacoustic amplitude increases proportionally to the increasing of illuminating light power. The imaging sensitivity and contrast, however, in this case are limited due to stronger background signals from intrinsic chromophores in biological tissue. The current work investigates the advantages of nonlinear photoacoustic generation compared to linear signal, by using a single-wavelength pump-probe and nanosecond-scale two-pulse excitation scheme. The results show that nonlinearity induced by this scheme yields higher detection sensitivity and contrast.

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Fei Cao, Zhihai Qiu, Kinfung Wong, Puxiang Lai, and Lei Sun "Nonlinear photoacoustic generation by pump-probe excitation", Proc. SPIE 10878, Photons Plus Ultrasound: Imaging and Sensing 2019, 108784R (27 February 2019); https://doi.org/10.1117/12.2507342

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