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6 March 2019 Simultaneous photoacoustic tomography guided diffuse optical tomography: a numerical study
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Abstract
A co-planar, simultaneous, photoacoustic tomography guided, diffused optical tomography (CS-PAT-DOT) methodology has been presented in this paper. We detect the absorption of sub-regions with different absorption characteristics in deep tissue with a high spatial resolution. To this aim, we initially utilize compressed sensing (CS), time reversal (TR) and back projection (BP) reconstruction algorithms to reconstruct a priori information inside a heterogeneous phantom. Then the reconstructed images are used in DOT image reconstruction through the total variation method. Improvements obtained from such hybrid methodology are measured by comparing DOT and CS-PAT-DOT images. It will also show that each of the reconstructions based on the proposed method has a unique capability to accurately detect heterogeneities in the tissue at different depths; significantly improving spatial resolution in DOT images. The focus of this study is directed towards quantifying the concentrations of endogenous chromophores, e.g., oxyhemoglobin, deoxyhemoglobin and cytochrome-c-oxidase etc., which are significant indices in detecting tissue abnormalities.
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Mehrdad Zarei, Sadreddin Mahmoodkalayeh, Mohammad Ali Ansari, Karl Kratkiewicz, Rayyan Manwar, and M. R. Nasiriavanaki "Simultaneous photoacoustic tomography guided diffuse optical tomography: a numerical study", Proc. SPIE 10878, Photons Plus Ultrasound: Imaging and Sensing 2019, 108785U (6 March 2019); https://doi.org/10.1117/12.2510554
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