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7 March 2019 Monitoring vascular targeted PDT response with multimode optical imaging
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Proceedings Volume 10879, Biophotonics and Immune Responses XIV; 1087906 (2019) https://doi.org/10.1117/12.2513578
Event: SPIE BiOS, 2019, San Francisco, California, United States
Abstract
Vascular targeted photodynamic therapy (V-PDT) has shown satisfied efficiency in treating vascular-related diseases including age-related macular degeneration, port-wine stains (PWS), and prostate cancer. Its efficacy is a complex function of photosensitizer (PS) uptake, oxygen concentration, PS-activating light dose and tissue optical properties. In order to non -invasively monitor PS distribution and photobleaching, blood vessel contraction and blood flow velocity for V-PDT response, a multimode optical imaging (MOI) system was developed to capture PS fluorescence image, narrow band image and laser speckle image, respectively. V-PDT in vivo studies were performed, which suggests that our MOI system is capable of monitoring dynamic response during V-PDT treatment.
© (2019) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Yi Shen, Fuqiang Liang, Yanhui Niu, Huiyun Lin, Ying Gu, Brian C. Wilson, and Buhong Li "Monitoring vascular targeted PDT response with multimode optical imaging", Proc. SPIE 10879, Biophotonics and Immune Responses XIV, 1087906 (7 March 2019); https://doi.org/10.1117/12.2513578
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