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7 March 2019 BSA-modified gold nanorods for combined photothermal therapy and immunotherapy of melanoma
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Proceedings Volume 10879, Biophotonics and Immune Responses XIV; 108790N (2019) https://doi.org/10.1117/12.2506097
Event: SPIE BiOS, 2019, San Francisco, California, United States
Abstract
Nanoparticle-based combination therapy may provide an effective therapeutic strategy. Herein, we show that bovine serum albumin (BSA)-bioinspired gold nanorods (GNRs) loaded with immunoadjuvant for combined photothermal therapy (PTT) and immunotherapy for treatment of melanoma. In this work, cetyltrimethylammonium bromide (CTAB) coated GNRs were successively decorated with polyethylene glycol (PEG) and BSA, and loaded with an immunoadjuvant imiquimod (R837). The synthesized mPEGGNRs@ BSA/R837 nanocomplexes could significantly induce immune response in vitro. Furthermore, under near-infrared (NIR) irradiation could effectively kill tumor cells. The nanocomplex-based PTT in combination with immunotherapy may be potentially employed as an effective strategy for the treatment of melanoma and other metastatic cancers.
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Benqing Zhou, Meng Wang, Feifan Zhou, Jun Song, Junle Qu, and Wei R. Chen "BSA-modified gold nanorods for combined photothermal therapy and immunotherapy of melanoma", Proc. SPIE 10879, Biophotonics and Immune Responses XIV, 108790N (7 March 2019); https://doi.org/10.1117/12.2506097
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