The characterization of graphene-reconstituted low-density lipoproteins and small molecule inhibitor nanoparticles in preparation for use in laser immunotherapy

Kyra A. Gallagher; Austin Doughty; Elivia Layton; Sara Zukerman; Benqing Zhou; Wei R. Chen

doi:10.1117/12.2506714

7 March 2019 The characterization of graphene-reconstituted low-density lipoproteins and small molecule inhibitor nanoparticles in preparation for use in laser immunotherapy

Kyra A. Gallagher, Austin Doughty, Elivia Layton, Sara Zukerman, Benqing Zhou, Wei R. Chen

Author Affiliations +

Proceedings Volume 10879, Biophotonics and Immune Responses XIV; 108790O (2019) https://doi.org/10.1117/12.2506714
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

We here report on the synthesis and characterization of two nanoparticles focused on cancer treatment via laser immunotherapy (LIT), which is a novel cancer treatment modality with the ability to eradicate primary tumors directly and induce an immune response to destroy distant metastases. This method makes use of a photosensitizing agent and an immunoadjuvant to aide in the efficacy and targeting of a laser treatment. In consideration of ways to bring those materials to the tumor site, we investigated the use of various nanoparticles as targeted delivery agents. Due to the tendency of cancerous cells to overexpress low-density lipoprotein receptors (LDLR) to fulfill their heightened need for cholesterol, as well as due to the previously documented ability of low-density lipoproteins (LDL) to be reconstituted with other materials, these naturally occurring nanoparticles served as the base to be combined with reduced graphene oxide (rGO) and form a therapeutic nanocompound dubbed rGO-LDL. (R)-9bMS, a small molecule inhibitor, is known to significantly hinder the proliferation of triple-negative breast cancer cells—a tumor model particularly resistant to treatment. For this reason, (R)-9bMS was selected, and the photosensitizing agent, indocyanine green (ICG) was combined with it into a nanoparticle geared towards use in LIT.

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Kyra A. Gallagher, Austin Doughty, Elivia Layton, Sara Zukerman, Benqing Zhou, and Wei R. Chen "The characterization of graphene-reconstituted low-density lipoproteins and small molecule inhibitor nanoparticles in preparation for use in laser immunotherapy", Proc. SPIE 10879, Biophotonics and Immune Responses XIV, 108790O (7 March 2019); https://doi.org/10.1117/12.2506714

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KEYWORDS

Nanoparticles

Cancer

Absorption

Molecules

Graphene

Molecular lasers

Oncology

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