Evaluation of anti-inflammatory, antioxidant activity and protective effect on ulcerative colitis of traditional Chinese medicine Lian-ai jian

Fan Shi; Zi-cong Wu; Zhen-ling Zhao; Tong-sheng Chen; Yi-fei Wang; Zhi-ping Wang

doi:10.1117/12.2508543

7 March 2019 Evaluation of anti-inflammatory, antioxidant activity and protective effect on ulcerative colitis of traditional Chinese medicine Lian-ai jian

Fan Shi, Zi-cong Wu, Zhen-ling Zhao, Tong-sheng Chen, Yi-fei Wang, Zhi-ping Wang

Author Affiliations +

Proceedings Volume 10879, Biophotonics and Immune Responses XIV; 108790V (2019) https://doi.org/10.1117/12.2508543
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Ulcerative colitis (UC) is a chronic and refractory inflammatory disorder of the colon and rectum with increasing morbidity in recent years. Lian-ai jian (LAJ), a Chinese medicinal herb decoction, including two herbs: Coptidis Rhizoma and Artemisiae Argyi Folium. We group them according to the ancient Chinese medical books "Songfengshuoyi", and investigate the anti-inflammatory, antioxidant activity and protective effect on UC of this compound. Dextran sulfate sodium salt (DSS)-induced colitis mice were used to assess its protective effect on UC. We also determined the anti-inflammatory ability of LAJ by measuring the inhibition of IL-1β, IL-6 and TNF-α expression in LPS stimulated RAW 264.7 macrophages. The inhibition of Nitric oxide (NO) production, iNOS expression in RAW 264.7 macrophages and extracellular NO scavenging ability were used as indicators to evaluate the antioxidant activity of LAJ. The results showed that LAJ had strong anti-inflammatory, antioxidant activity and reduced the disease activity index and colon shortening of mice.

Citation Download Citation

Fan Shi, Zi-cong Wu, Zhen-ling Zhao, Tong-sheng Chen, Yi-fei Wang, and Zhi-ping Wang "Evaluation of anti-inflammatory, antioxidant activity and protective effect on ulcerative colitis of traditional Chinese medicine Lian-ai jian", Proc. SPIE 10879, Biophotonics and Immune Responses XIV, 108790V (7 March 2019); https://doi.org/10.1117/12.2508543

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