Simultaneous reconstruction and displacement estimation for spectral-domain optical coherence elastography

Jonathan H. Mason; Yvonne Reinwald; Ying Yang; Sarah Waters; Alicia El Haj; Pierre O. Bagnaninchi

doi:10.1117/12.2508326

21 February 2019 Simultaneous reconstruction and displacement estimation for spectral-domain optical coherence elastography

Jonathan H. Mason, Yvonne Reinwald, Ying Yang, Sarah Waters, Alicia El Haj, Pierre O. Bagnaninchi

Author Affiliations +

Proceedings Volume 10880, Optical Elastography and Tissue Biomechanics VI; 108801K (2019) https://doi.org/10.1117/12.2508326
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Optical coherence elastography allows the characterization of the mechanical properties of tissues, and can be performed through estimating local displacement maps from subsequent acquisitions of a sample under different loads. This displacement estimation is limited by noise in the images, which can be high in dynamic systems due to the inability to perform long exposures or B-scan averaging. In this work, we propose a framework for simultaneously enhancing both the image quality and displacement map for elastography, by motion compensated denoising with the block-matching and 4D filtering (BM4D) method, followed by a re-estimation of displacement. We adopt the interferometric synthetic aperture microscopy (ISAM) method to enhance the lateral resolution away from the focal plane, and use sub-pixel cross correlation block matching for non-uniform deformation estimation. We validate this approach on data from a commercial spectral domain optical coherence tomography system, whereby we observe an enhancement of both image and displacement accuracy of up to 33% over a standard approach.

Citation Download Citation

Jonathan H. Mason, Yvonne Reinwald, Ying Yang, Sarah Waters, Alicia El Haj, and Pierre O. Bagnaninchi "Simultaneous reconstruction and displacement estimation for spectral-domain optical coherence elastography", Proc. SPIE 10880, Optical Elastography and Tissue Biomechanics VI, 108801K (21 February 2019); https://doi.org/10.1117/12.2508326

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